Article
Correlations between T-cell specificity and the structure of the antigen receptor.
Nature - 1 Jan 2000
Fink P J, Matis L A, McElligott D L, Bookman M, Hedrick S M
Abstract excerpt
The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Clone Cells
- Columbidae
- Cytochrome c Group
- DNA
- Genes, MHC Class II
- Lymphocyte Activation
- Mutation
- Receptors, Antigen, T-Cell
- Recombination, Genetic