Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.

Nature - 2 Mar 1995

Elling C E, Nielsen S M, Schwartz T W

Abstract excerpt

Mutational analysis of the tachykinin NK-1 (refs 1-7), NK-2 (ref. 8) and angiotensin AT-1 (refs 9, 10) receptors indicates that non-peptide antagonists act through residues located between the seven transmembrane segments, whereas natural peptide agonists bind mainly to residues scattered in the exterior part of the receptor. The presumed contact points for the prototype NK-1 antagonist CP96,345 cluster on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histidine

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Conformation

Source

Identifiers

PMID: 7532789
DOI: 10.1038/374074a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.PMID 7532789Read ↗

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor.Semantic proximity Read ↗

Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor.Semantic proximity Read ↗

Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD.Semantic proximity Read ↗

Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.Semantic proximity Read ↗

Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected].Semantic proximity Read ↗

Effect of mutation of Phe 2436.44 of the histamine H2 receptor on cimetidine and ranitidine mechanism of action.Semantic proximity Read ↗

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.Semantic proximity Read ↗

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.Semantic proximity Read ↗

Engineering an interfacial zinc site to increase hormone-receptor affinity.Semantic proximity Read ↗

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC).Semantic proximity Read ↗

Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein.Semantic proximity Read ↗

The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.