Article
Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected].
The Journal of biological chemistry - 30 Sept 1994
Gether U, Nilsson L, Lowe J A, Schwartz T W
Abstract excerpt
Previously we have found that binding of the nonpeptide substance P antagonist, CP 96,345, to the neurokinin-1 (NK-1) receptor was critically dependent on two short segments adjacent to the top of transmembrane segments (TM) V and VI, called segments A (residues 183-195) and D (residues 271-276),...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Biphenyl Compounds
- Cells, Cultured
- Hypnotics and Sedatives
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Receptors, Neurokinin-1