Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.

doi:10.1074/jbc.M202103200

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Article

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.

The Journal of biological chemistry - 6 Dec 2002

Holst Birgitte, Elling Christian E, Schwartz Thue W

Abstract excerpt

An endogenous metal-ion site in the melanocortin MC1 and MC4 receptors was characterized mainly in transiently transfected COS-7 cells. ZnCl(2) alone stimulated signaling through the Gs pathway with a potency of 11 and 13 microm and an efficacy of 50 and 20% of that of alpha-melanocortin stimulating hormone (alpha-MSH) in the MC1 and MC4 receptors, respectively. In the presence of peptide agonist, Zn(II) acted as...

Topics

Amino Acid Sequence
Animals
Binding, Competitive
Brain
COS Cells
Cyclic AMP
Cysteine
DNA, Complementary
Dose-Response Relationship, Drug
Humans
Inhibitory Concentration 50
Ions
Kinetics
Ligands
Metals

Source

Open in PubMed

Identifiers

PMID: 12244039
DOI: 10.1074/jbc.M202103200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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