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Article

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.

The Journal of biological chemistry - 6 Dec 2002

Holst Birgitte, Elling Christian E, Schwartz Thue W

Abstract excerpt

An endogenous metal-ion site in the melanocortin MC1 and MC4 receptors was characterized mainly in transiently transfected COS-7 cells. ZnCl(2) alone stimulated signaling through the Gs pathway with a potency of 11 and 13 microm and an efficacy of 50 and 20% of that of alpha-melanocortin stimulating hormone (alpha-MSH) in the MC1 and MC4 receptors, respectively. In the presence of peptide agonist, Zn(II) acted as...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12244039
DOI: 10.1074/jbc.M202103200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.PMID 12244039Read ↗

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