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Article

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC).

Biochemical pharmacology - 1 Nov 2021

Madjroh Nawid, Mellou Eleni, Æbelø Laura, Davies Paul A, Söderhielm Pella C, Jensen Anders A

Abstract excerpt

The molecular basis for the signal transduction through the classical Cys-loop receptors (CLRs) has been delineated in great detail. The Zinc-Activated Channel (ZAC) constitutes a so far poorly elucidated fifth branch of the CLR superfamily, and in this study we explore the molecular mechanisms underlying ZAC signaling in Xenopus oocytes by two-electrode voltage clamp electrophysiology. In studies of chimeric...

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Identifiers

PMID: 34560053
DOI: 10.1016/j.bcp.2021.114781
PMCID: PMC11359809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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