Article
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1991
Brannan C I, Lyman S D, Williams D E, Eisenman J, Anderson D M, Cosman D, Bedell M A, Jenkins N A, Copeland N G
Abstract excerpt
Mice homozygous for the viable Sl allele steel-Dickie (Sld) are sterile, severely anemic, and black-eyed white. The nature of the Sld mutation was investigated at the molecular level and was found to be due to a 4.0-kilobase intragenic deletion in mast cell growth factor (MGF) genomic sequences,...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Cell Membrane
- Chromosome Deletion
- Cytoplasm
- DNA
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction