Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice.

doi:10.1210/endo-127-3-1033

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Article

Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice.

Endocrinology - 1 Sept 1990

Behringer R R, Lewin T M, Quaife C J, Palmiter R D, Brinster R L, D'Ercole A J

Abstract excerpt

A line of transgenic mice expressing insulin-like growth factor-I (IGF-I) under the control of the mouse metallothionien-1 promoter was crossed to a line of dwarf transgenic mice lacking GH expressing cells that were genetically ablated by diphtheria toxin expression. Mice generated from this cross that carry both transgenes express IGF-I in the absence of GH. These mice grew larger than their GH-deficient...

Topics

Aging
Animals
Body Weight
Bone Development
Brain
Diphtheria Toxin
Female
Gene Expression
Genotype
Growth
Growth Hormone
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Male

Metallothionein

Mice

Mice, Transgenic

Organ Size

Source

Open in PubMed

Identifiers

PMID: 2387246
DOI: 10.1210/endo-127-3-1033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2387246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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