Article
Expression of insulin-like growth factor-I in transgenic mice.
Annals of the New York Academy of Sciences - 27 Aug 1993
D'Ercole A J
Abstract excerpt
The studies reviewed above provide strong evidence for the concept that IGF-I plays an essential role in mediating the growth-promoting actions of GH, and thus, they support the central elements of the "somatomedin hypothesis." The data, however, also point to actions of each GH and IGF-I that are not linked. Many hormones and factors, other than GH, are known to regulate the expression of IGF-I, as well as its...
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