Expression of insulin-like growth factor-I in transgenic mice.

doi:10.1111/j.1749-6632.1993.tb26213.x

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Article

Expression of insulin-like growth factor-I in transgenic mice.

Annals of the New York Academy of Sciences - 27 Aug 1993

D'Ercole A J

Abstract excerpt

The studies reviewed above provide strong evidence for the concept that IGF-I plays an essential role in mediating the growth-promoting actions of GH, and thus, they support the central elements of the "somatomedin hypothesis." The data, however, also point to actions of each GH and IGF-I that ar...

Topics

Aging
Animals
Bone Development
Brain
DNA
DNA, Complementary
Gene Expression
Growth Hormone
Humans
Insulin-Like Growth Factor I
Mice
Mice, Transgenic
Phenotype

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