Article
Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice: characterization and insights into the regulation of IGFBP-1 expression.
Endocrinology - 1 Oct 1994
Dai Z, Xing Y, Boney C M, Clemmons D R, D'Ercole A J
Abstract excerpt
Three hemizygous transgenic (Tg) mouse lines were generated with a fusion gene composed of the mouse metallothionein promoter (mMT-I) and a full-length human insulin-like growth factor binding protein-1 (hIGFBP-1) complementary DNA that was truncated in its 3'-untranslated region. Despite high serum hIGFBP-1 levels (120-2570 micrograms/liter) before puberty in two of these lines, no significant alterations were...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Brain Chemistry
- Carrier Proteins
- Cycloheximide
- DNA
- Fasting
- Gene Expression Regulation
- Insulin-Like Growth Factor Binding Protein 1