Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotoxicity of streptozotocin.

Mutation research - 1 Dec 2002

Bolzán Alejandro D, Bianchi Martha S

Abstract excerpt

Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells. STZ is a potent alkylating agent known to directly methylate DNA and is highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Antioxidants
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chelating Agents

Share to Chromosome Breakage

Share to Free Radicals

Share to Mutagenicity Tests

Share to Streptozocin

Source

Identifiers

PMID: 12464347
DOI: 10.1016/s1383-5742(02)00044-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotoxicity of streptozotocin.PMID 12464347Read ↗

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humansSemantic proximity Read ↗

Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line.Semantic proximity Read ↗

Streptozotocin-induced genotoxic effects in Chinese hamster cells: the resistant phenotype of V79 cells.Semantic proximity Read ↗

Tissue-specific induction of mutations by streptozotocin in vivo.Semantic proximity Read ↗

Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells.Semantic proximity Read ↗

Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells.Semantic proximity Read ↗

Assessment of antimutagenic effects of stobadine dihydrochloride on MNNG-induced mutations in Chinese hamster cells V79.Semantic proximity Read ↗

Unequivocal evidence of genotoxic potential of argemone oil in miceSemantic proximity Read ↗

Mutagenicity of saccharin in a human cell strain.Semantic proximity Read ↗

Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432.Semantic proximity Read ↗

Genotoxicity induced by saponified coconut oil surfactant in prokaryote systems.Semantic proximity Read ↗

The genotoxicity of sodium saccharin and sodium chloride in relation to their cancer-promoting properties.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.