Article
Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells.
Mutation research - 7 Aug 1998
Chinnasamy N, Fairbairn L J, Laher J, Willington M A, Rafferty J A
Abstract excerpt
The murine bone marrow micronucleus assay has been used to examine (1) the potentiation of fotemustine and streptozotocin induced-clastogenicity by the O6-alkylguanine-DNA alkyltransferase (ATase) inactivator O6-benzylguanine (O6-beG) and (2) the level of protection afforded against this potentia...
Topics
- Alkyl and Aryl Transferases
- Alkylating Agents
- Animals
- Bone Marrow Cells
- Bone Marrow Transplantation
- DNA Repair
- Drug Synergism
- Enzyme Inhibitors
- Female
- Gene Expression
- Guanine
- Humans
- Male
- Mice
- Micronucleus Tests
- Mutagens
- Mutation
- Nitrosourea Compounds