Article
The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.
BMC cancer - 22 Oct 2010
Tang Kefu, Li Yang, Zhang Zhao, Gu Yunmin, Xiong Yuyu, Feng Guoyin, He Lin, Qin Shengying
Abstract excerpt
BACKGROUND: CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of cancer. The PstI/RsaI and DraI polymorphism are two of the most commonly studied polymorphisms of the gene for their association with risk of head and neck cancer, but the results are...
Topics
- Asian People
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cytochrome P-450 CYP2E1
- Deoxyribonucleases, Type II Site-Specific
- Genetic Predisposition to Disease
- Genotype
- Head and Neck Neoplasms
- Homozygote
- Humans
- Polymorphism, Genetic
- Risk