Article
An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.
Japanese journal of cancer research : Gann - 1 Mar 1995
Watanabe J, Yang J P, Eguchi H, Hayashi S, Imai K, Nakachi K, Kawajiri K
Abstract excerpt
CYP2E1 catalyzes the metabolic activation of tobacco-specific N-nitrosamines, including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. An Rsa I polymorphism, which is located in the 5'-flanking region of the CYP2E1 gene, has been found to affect the transcriptional regulation of the gene, resulting in different expression levels of the mRNA among individuals. In order to investigate an association between the...
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