Article
An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.
Japanese journal of cancer research : Gann - 1 Mar 1995
Watanabe J, Yang J P, Eguchi H, Hayashi S, Imai K, Nakachi K, Kawajiri K
Abstract excerpt
CYP2E1 catalyzes the metabolic activation of tobacco-specific N-nitrosamines, including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. An Rsa I polymorphism, which is located in the 5'-flanking region of the CYP2E1 gene, has been found to affect the transcriptional regulation of the gene, result...
Topics
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Deoxyribonucleases, Type II Site-Specific
- Gene Expression
- Genotype
- Humans
- Japan
- Lung Neoplasms
- Oxidoreductases, N-Demethylating
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- RNA, Messenger
- Regulatory Sequences, Nucleic Acid
- Risk Factors