Article
Genotoxicity assessments of N-nitrosoethylisopropylamine (NEIPA) and N-nitrosodiisopropylamine (NDIPA) in the C57BL/6J mouse.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000
Ye Qian, Geng Xingchao, Jiang Hua, Qin Chao, Wu Hui, Wang Sanlong, Wen Hairuo
Abstract excerpt
N-Nitrosamines, known as drug impurities and suspected carcinogens, have drawn significant public concern. In response to drug regulatory needs, the European Medicines Agency (EMA) has previously proposed a carcinogenic potency categorization approach based on the N-nitrosamine α-hydroxylation hypothesis, i.e., that N-nitrosamine mutagenicity increases with the number of α-hydrogen atoms. However, this...
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