Structure-activity relationships in mutagenicity and in nucleophilic ring opening of N-(arylmethyl)phenanthrene 9,10-imines.

doi:10.1093/mutage/5.1.25

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Article

Structure-activity relationships in mutagenicity and in nucleophilic ring opening of N-(arylmethyl)phenanthrene 9,10-imines.

Mutagenesis - 1 Jan 1990

Roll M, Shtelzer S, Stark A A, Blum J

Abstract excerpt

Ten derivatives of N-benzylphenanthrene 9,10-imine with different substituents on the phenyl ring were synthesized and subjected to mutagenicity tests in Salmonella typhimurium TA100. While electron donating groups were found to enhance the biological activity, electron attracting and bulky subst...

Topics

Chemical Phenomena
Chemistry
Electrons
Imines
Kinetics
Magnetic Resonance Spectroscopy
Molecular Structure
Mutagenicity Tests
Mutation
Phenanthrenes
Salmonella typhimurium
Structure-Activity Relationship

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