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Article

N-Nitrosodiethylamine mutagenicity at low concentrations.

Toxicology letters - 1 Nov 2003

Aiub Claudia Alessandra Fortes, Pinto Luis Felipe Ribeiro, Felzenszwalb Israel

Abstract excerpt

N-Nitrosodiethylamine (NDEA) requires metabolic activation by cytochrome P450 enzymes, leading to electrophile species that react in DNA. Although, carcinogenicity is not an end point in genotoxicity assays, NDEA has been considered a weak carcinogen. In this study, we carried out an analysis of the mutagenicity at low concentrations of NDEA. Using SOS chromotest in the presence of metabolic activation, we...

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PMID: 12962972
DOI: 10.1016/s0378-4274(03)00263-7

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