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Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration.

Regulatory toxicology and pharmacology : RTP - 1 Apr 2015

Fei Chenzhong, Zhang Jie, Lin Yang, Wang Xiaoyang, Zhang Keyu, Zhang Lifang, Zheng Wenli, Wang Mi, Li Tao, Xiao Sui, Xue Feiqun, Wang Chunmei

Abstract excerpt

Nitromezuril (NZL) is a novel triazine compound that exhibits remarkable anticoccidial activity. However, mutagenicity and genotoxicity of NZL have not been evaluated to date. This study evaluated the potential risks of NZL by testing for bacterial reverse mutation (Ames), mouse sperm abnormality (SA), bone marrow micronucleus (MN) and chromosomal aberration (CA). Mice were orally administered with NZL at 385,...

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PMID: 25645284
DOI: 10.1016/j.yrtph.2015.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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