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Article

The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.

The Journal of biological chemistry - 21 May 1999

Hoffmann C, Moro S, Nicholas R A, Harden T K, Jacobson K A

Abstract excerpt

The P2Y1 receptor is a membrane-bound G protein-coupled receptor stimulated by adenine nucleotides. Using alanine scanning mutagenesis, the role in receptor activation of charged amino acids (Asp, Glu, Lys, and Arg) and cysteines in the extracellular loops (EL) of the human P2Y1 receptor has been investigated. The mutant receptors were expressed in COS-7 cells and measured for stimulation of phospholipase C...

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Identifiers

PMID: 10329657
DOI: 10.1074/jbc.274.21.14639
PMCID: PMC3449168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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