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Article

The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors.

Molecular endocrinology (Baltimore, Md.) - 1 May 1999

Luck M D, Carter P H, Gardella T J

Abstract excerpt

Recent mutagenesis and cross-linking studies suggest that residues in the carboxyl-terminal portion of PTH(1-34) interact with the amino-terminal extracellular domain of the receptor and thereby contribute strongly to binding energy; and that residues in the amino-terminal portion of the ligand interact with the receptor region containing the transmembrane helices and extracellular loops and thereby induce second...

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Source

Identifiers

PMID: 10319318
DOI: 10.1210/mend.13.5.0277

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors.PMID 10319318Read ↗

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Mutation of phenylalanine-34 of parathyroid hormone disrupts NHERF1 regulation of PTH type I receptor signaling.Semantic proximity Read ↗

Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling.Semantic proximity Read ↗

Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.Semantic proximity Read ↗

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Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations.Semantic proximity Read ↗

Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation.Semantic proximity Read ↗

Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.Semantic proximity Read ↗

Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).Semantic proximity Read ↗

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