The carboxy-terminus of parathyroid hormone is essential for hormone processing and secretion.

doi:10.1210/endo.131.5.1425431

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Article

The carboxy-terminus of parathyroid hormone is essential for hormone processing and secretion.

Endocrinology - 1 Nov 1992

Lim S K, Gardella T J, Baba H, Nussbaum S R, Kronenberg H M

Abstract excerpt

The biological function of the carboxy-terminal portion of the PTH molecule is unknown. We hypothesized that the carboxy-terminus of PTH may be essential for hormone processing and secretion. To ascertain the potential role of the carboxy-terminus in transport through the secretory pathway, we co...

Topics

Animals
Biological Transport
Cell Line
Endoplasmic Reticulum
Mutation
Parathyroid Hormone
Precipitin Tests
Protein Biosynthesis
Protein Kinase C
Protein Precursors
Radioimmunoassay

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