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Article

The carboxy-terminus of parathyroid hormone is essential for hormone processing and secretion.

Endocrinology - 1 Nov 1992

Lim S K, Gardella T J, Baba H, Nussbaum S R, Kronenberg H M

Abstract excerpt

The biological function of the carboxy-terminal portion of the PTH molecule is unknown. We hypothesized that the carboxy-terminus of PTH may be essential for hormone processing and secretion. To ascertain the potential role of the carboxy-terminus in transport through the secretory pathway, we constructed a series of carboxy-terminally deleted mutants of human preproPTH. PreproPTH and these truncated peptides...

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Source

Identifiers

PMID: 1425431
DOI: 10.1210/endo.131.5.1425431

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The carboxy-terminus of parathyroid hormone is essential for hormone processing and secretion.PMID 1425431Read ↗

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Homozygous Ser-1 to Pro-1 mutation in parathyroid hormone identified in hypocalcemic patients results in secretion of a biologically inactive pro-hormone.Semantic proximity Read ↗

Evolutionary well-conserved region in the signal peptide of parathyroid hormone-related protein is critical for its dual localization through the regulation of ER translocation.Semantic proximity Read ↗

Parathyroid Hormone-Related Protein as a Prohormone: Posttranslational Processing and Receptor Interactions*Semantic proximity Read ↗

A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export.Semantic proximity Read ↗

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The carboxy-terminus, a key regulator of protein functionSemantic proximity Read ↗

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Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.Semantic proximity Read ↗

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