Article
HIV-1 reverse transcriptase mutations found in a drug-experienced patient confer reduced susceptibility to multiple nucleoside reverse transcriptase inhibitors.
Antiviral therapy - 1 Dec 2001
Fitzgibbon J E, DiCola B, Arnold E, Das K, Sha B E, Pottage J C, Nahass R, Gaur S, John J F
Abstract excerpt
HIV-1 reverse transcriptase (RT) genotypes were obtained from 13 patients treated with stavudine. No previously-reported mutations indicative of stavudine resistance were found in these patients and no novel mutations occurred in more than two patients. One patient, treated with stavudine for 1 month and treated previously with zidovudine, zalcitabine and lamivudine, carried a mutation at codon 75 of the RT...
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