Article
Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991
Richman D, Shih C K, Lowy I, Rose J, Prodanovich P, Goff S, Griffin J
Abstract excerpt
We have recently described a nonnucleoside compound that specifically inhibits the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS. This compound, nevirapine (BI-RG-587), interacts with highly conserved tyrosine residues at positions 181 and 188 i...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Azepines
- Base Sequence
- Cell Line
- Culture Techniques
- Genetic Variation
- Genome, Viral
- HIV-1
- HeLa Cells
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation