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Article

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991

Richman D, Shih C K, Lowy I, Rose J, Prodanovich P, Goff S, Griffin J

Abstract excerpt

We have recently described a nonnucleoside compound that specifically inhibits the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS. This compound, nevirapine (BI-RG-587), interacts with highly conserved tyrosine residues at positions 181 and 188 in the reverse transcriptase to inhibit the recombinant enzyme and virus replication in cell culture with 50% inhibitory...

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Identifiers

PMID: 1722324
DOI: 10.1073/pnas.88.24.11241
PMCID: PMC53110

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