Article
Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression.
Stroke - 1 Aug 1996
Lo E H, Hara H, Rogowska J, Trocha M, Pierce A R, Huang P L, Fishman M C, Wolf G L, Moskowitz M A
Abstract excerpt
BACKGROUND AND PURPOSE: Mice containing deletions in the genes encoding nitric oxide (NO) synthase have been useful to dissect the role of NO in cerebral ischemia. We recently reported that mice lacking expression of the endothelial isoform of NO synthase (eNOS) develop larger infarcts after middle cerebral artery occlusion. Because NO or a related product of NO synthase activity is important for relaxation of...
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