Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.

Stroke - 1 Aug 2010

Atochin Dmitriy N, Yuzawa Izumi, Li Qian, Rauwerdink Kristen M, Malhotra Rajeev, Chang Junlei, Brouckaert Peter, Ayata Cenk, Moskowitz Michael A, Bloch Kenneth D, Huang Paul L, Buys Emmanuel S

Abstract excerpt

BACKGROUND AND PURPOSE: Nitric oxide mediates endothelium-dependent vasodilation, modulates cerebral blood flow, and determines stroke outcome. Nitric oxide signals in part by stimulating soluble guanylate cyclase (sGC) to synthesize cGMP. To study the role of sGC in stroke injury, we compared the outcome of cerebral ischemia and reperfusion in mice deficient in the alpha(1) subunit of sGC (sGCalpha(1)(-/-)) with...

Topics

Animals
Blood Pressure
Cerebrovascular Circulation
Genotype
Guanylate Cyclase
Infarction, Middle Cerebral Artery
Mice
Mice, Knockout
Nitric Oxide
Reperfusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reperfusion Injury

Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 20595671
DOI: 10.1161/STROKEAHA.109.577635
PMCID: PMC3047459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.PMID 20595671Read ↗

Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.Semantic proximity Read ↗

Animal models of ischemic cerebral small vessel disease: A narrative review of pathological phenotypes, challenges, and future directions.Semantic proximity Read ↗

Genetic modification of hypertension by sGCα1.Semantic proximity Read ↗

Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells.Semantic proximity Read ↗

Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain InjurySemantic proximity Read ↗

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.Semantic proximity Read ↗

Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient miceSemantic proximity Read ↗

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans.Semantic proximity Read ↗

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.Semantic proximity Read ↗

Dysfunctional nitric oxide signalling increases risk of myocardial infarction.Semantic proximity Read ↗

Gα <sub>q/11</sub> signalling counteracts endothelial dysfunction in the brain and protects cognition in aged miceSemantic proximity Read ↗

Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.