Article
Major histocompatibility complex-controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific.
European journal of immunology - 1 Jun 1997
Issazadeh S, Kjellén P, Olsson T, Mustafa M, Holmdahl R
Abstract excerpt
The myelin basic protein (MBP) peptide 63-88-induced experimental autoimmune encephalomyelitis (EAE) and its associated T cell cytokine profile are influenced by the rat major histocompatibility complex (MHC). There is an allele-specific protective influence of the MHC class I region, whereas the...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Disease Susceptibility
- Encephalomyelitis, Autoimmune, Experimental
- Epitope Mapping
- Epitopes
- Immunodominant Epitopes
- Major Histocompatibility Complex
- Molecular Sequence Data
- Myelin Basic Protein
- Peptide Fragments
- Rats
- Rats, Inbred Lew