Article
Major histocompatibility complex-controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific.
European journal of immunology - 1 Jun 1997
Issazadeh S, Kjellén P, Olsson T, Mustafa M, Holmdahl R
Abstract excerpt
The myelin basic protein (MBP) peptide 63-88-induced experimental autoimmune encephalomyelitis (EAE) and its associated T cell cytokine profile are influenced by the rat major histocompatibility complex (MHC). There is an allele-specific protective influence of the MHC class I region, whereas the MHC class II region display either disease-protective or -promoting effects. To investigate if the MHC-associated...
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