Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains.

doi:10.1038/sj.gene.6363761

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Article

Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains.

Genes and immunity - 1 Jun 2001

Furuya T, Joe B, Salstrom J L, Hashiramoto A, Dobbins D E, Wilder R L, Remmers E F

Abstract excerpt

Inbred rat strains manifest remarkable differences in susceptibility/severity to autoimmune disease. MHC alleles strongly influence the pathogenesis of autoimmune disease in rats, but the precise mechanism(s) remain inadequately defined. The TNFalpha gene is located in the class III region of the MHC. Polymorphisms, influencing either the structure or expression of the TNF protein, might contribute to differences...

Topics

Animals
Autoimmune Diseases
Base Sequence
DNA Primers
Genetic Predisposition to Disease
Polymorphism, Genetic
Rats
Tumor Necrosis Factor-alpha

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Open in PubMed

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PMID: 11477479
DOI: 10.1038/sj.gene.6363761

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