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Article

Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity.

International immunology - 1 Dec 1999

de Graaf K L, Weissert R, Kjellén P, Holmdahl R, Olsson T

Abstract excerpt

The impact of the strength and promiscuity of the self peptide-MHC class II interaction on susceptibility to autoimmune disease is uncertain. Here we studied allelic differences in the affinity of rat MHC class II molecules for myelin basic protein (MBP) peptides spanning from position 63 to 106. Predominantly peptides from this region are immunogenic in the rat and the MHC class II region determines if the...

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Share to Disease Susceptibility
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

Share to Myelin Basic Protein

Share to Peptide Fragments

Share to Rats, Inbred Lew

Source

Identifiers

PMID: 10590264
DOI: 10.1093/intimm/11.12.1981

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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