Parental genes do not codominantly confer susceptibility to experimental autoimmune encephalomyelitis in F1 rats.

doi:10.1016/s0165-5728(01)00244-2

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Article

Parental genes do not codominantly confer susceptibility to experimental autoimmune encephalomyelitis in F1 rats.

Journal of neuroimmunology - 1 Mar 2001

Lenz D C, Wolf N A, Swanborg R H

Abstract excerpt

Lewis (LEW) and DA rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with guinea pig myelin basic protein (MBP), but respond to different epitopes. The dominant epitope for LEW rats is MBP73-86, and disease is mediated primarily by Vbeta8.2 Th1 cells. DA rats lack conventional Vbeta8.2 T cells and do not respond to MBP73-86. Rather, DA rats respond to the cryptic epitope...

Topics

Adoptive Transfer
Amino Acid Sequence
Animals
Antigen Presentation
Cell Division
Encephalomyelitis, Autoimmune, Experimental
Female
Flow Cytometry
Genetic Predisposition to Disease
Immunodominant Epitopes
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-gamma

Molecular Sequence Data

Myelin Basic Protein

Rats

Rats, Inbred Lew

T-Lymphocytes

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 11240030
DOI: 10.1016/s0165-5728(01)00244-2

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