Article
Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis-resistant derivative, LER, and their impact on the inheritance of EAE resistance.
European journal of immunology - 1 Sept 1991
Blankenhorn E P, Stranford S A, Smith P D, Hickey W F
Abstract excerpt
Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, th...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- DNA Probes
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental
- HLA-DQ Antigens
- Immunity, Innate
- Molecular Sequence Data
- Myelin Basic Protein
- Polymorphism, Restriction Fragment Length