Article
Locations of antibody binding sites within conserved regions of the hepatitis C virus core protein.
Journal of medical virology - 1 May 1994
Sällberg M, Pumpen P, Zhang Z X, Lundholm P, Gusars I, Rudén U, Wahren B, Magnius L O
Abstract excerpt
The binding sites for human antibodies recognising antigenic domains within the hepatitis C virus (HCV) core protein were analyzed using synthetic peptides. Omission peptide analogues where a pair of residues was sequentially omitted were produced corresponding to the regions 1-18, 11-28, 21-38, 51-68, and 101-118. The N-terminal part of HCV core was found to contain three distinct antibody binding sites, which...
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