Article
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.
Blood - 15 Sept 1994
Lieschke G J, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler K J, Basu S, Zhan Y F, Dunn A R
Abstract excerpt
Mice lacking granulocyte colony-stimulating factor (G-CSF) were generated by targeted disruption of the G-CSF gene in embryonal stem cells. G-CSF-deficient mice (genotype G-CSF-/-) are viable, fertile, and superficially healthy, but have a chronic neutropenia. Peripheral blood neutrophil levels were 20% to 30% of wild-type mice (genotype G-CSF+/+) and mice heterozygous for the null mutation had intermediate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.