Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.

Abstract excerpt

Mice lacking granulocyte colony-stimulating factor (G-CSF) were generated by targeted disruption of the G-CSF gene in embryonal stem cells. G-CSF-deficient mice (genotype G-CSF-/-) are viable, fertile, and superficially healthy, but have a chronic neutropenia. Peripheral blood neutrophil levels were 20% to 30% of wild-type mice (genotype G-CSF+/+) and mice heterozygous for the null mutation had intermediate...

Topics

• Animals
• Base Sequence
• Genotype
• Granulocyte Colony-Stimulating Factor
• Granulocytes
• Hematopoiesis
• Hematopoietic Stem Cells
• Leukocyte Count
• Listeriosis
• Macrophages