Inherited disorders of granulopoiesis: understanding pathogenesis to advance new therapies.

Abstract excerpt

The central importance of neutrophils for human health is clearly demonstrated by the clinical presentation of patients with severe congenital neutropenia (CN) and cyclic neutropenia (CyN). The majority of patients with CN with neutropenia as their only symptom do not survive the first year of life unless they are treated with recombinant human cytokine granulocyte colony-stimulating factor (rhG-CSF) or undergo...

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