Article
Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia.
Blood - 1 Jul 1998
Hermans M H, Ward A C, Antonissen C, Karis A, Löwenberg B, Touw I P
Abstract excerpt
Mutations in the granulocyte colony-stimulating factor (G-CSF) receptor gene are found in a number of patients with severe chronic neutropenia predisposed to acute myeloid leukemia. These mutations result in the absence of the C-terminal domain of the G-CSF-R, a region which has been implicated i...
Topics
- Animals
- Chronic Disease
- Granulocyte Colony-Stimulating Factor
- Granulocytes
- Hematopoiesis
- Mice
- Mutation
- Neutropenia
- Receptors, Granulocyte Colony-Stimulating Factor
- Recombination, Genetic