Article
Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.
The Journal of clinical investigation - 1 Aug 1998
McLemore M L, Poursine-Laurent J, Link D C
Abstract excerpt
The role of mutations of the granulocyte colony-stimulating factor receptor (G-CSFR) in the pathogenesis of severe congenital neutropenia (SCN) and the subsequent development of acute myeloid leukemia (AML) is controversial. Mice carrying a targeted mutation of their G-CSFR that reproduces the mu...
Topics
- Acute Disease
- Animals
- Apoptosis
- Bone Marrow
- Cell Division
- Disease Susceptibility
- Female
- Genotype
- Granulocyte Colony-Stimulating Factor
- Hematopoiesis
- Humans
- Leukemia, Myeloid
- Male
- Mice