STAT3 controls myeloid progenitor growth during emergency granulopoiesis

doi:10.1182/blood-2009-12-259630

Article

STAT3 controls myeloid progenitor growth during emergency granulopoiesis

26 Jun 2010

Abstract excerpt

Granulocyte colony-stimulating factor (G-CSF) mediates "emergency" granulopoiesis during infection, a process that is mimicked by clinical G-CSF use, yet we understand little about the intracellular signaling cascades that control demand-driven neutrophil production. Using a murine model with conditional deletion of signal transducer and activator of transcription 3 (STAT3) in bone marrow, we investigated the...

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