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Article

p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers.

Cancer research - 15 Dec 2011

Sundaram Prema, Hultine Stacy, Smith Lauren M, Dews Michael, Fox Jamie L, Biyashev Dauren, Schelter Janell M, Huang Qihong, Cleary Michele A, Volpert Olga V, Thomas-Tikhonenko Andrei

Abstract excerpt

Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even slightly increased despite frequent loss of p53. Here, we determined that in HCT116 CRC cells, p53 activates the THBS1 primary transcript, but fails to boost THBS1 mRNA or protein levels, implying...

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Identifiers

PMID: 22028325
DOI: 10.1158/0008-5472.CAN-11-1124
PMCID: PMC3242824

Genes

THBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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