Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells.

Cancer letters - 28 Feb 2003

Harada Hironobu, Nakagawa Kou, Saito Masahiro, Kohno Shohei, Nagato Shigeyuki, Furukawa Koji, Kumon Yoshiaki, Hamada Katsuyuki, Ohnishi Takanori

Abstract excerpt

Malignant gliomas are distinguished from low-grade gliomas by their intense angiogenesis. In gliomas, p53 is the most frequently altered gene and is involved in the early phase of glioma development. In contrast, homozygous p16 gene deletion is more common in high-grade gliomas. In order to understand the mechanism by which gliomas become more angiogenic during the malignant transformation, we examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviruses, Human
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclins

Share to Genes, p16

Share to Neovascularization, Pathologic

Share to RNA, Neoplasm

Share to Thrombospondin 1

Share to Transduction, Genetic

Source

Identifiers

PMID: 12609716
DOI: 10.1016/s0304-3835(02)00592-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells.PMID 12609716Read ↗

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.Semantic proximity Read ↗

Expression of the thrombospondin 1 fragment 167–569 in C6 glioma cells stimulates tumorigenicity despite reduced neovascularizationSemantic proximity Read ↗

The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.Semantic proximity Read ↗

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.Semantic proximity Read ↗

P53 gene mutation and expression of MDM2, P53, P16 protein and their relationship in human glioma.Semantic proximity Read ↗

Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene.Semantic proximity Read ↗

Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status.Semantic proximity Read ↗

Induction of senescence in human malignant glioma cells by p16INK4A.Semantic proximity Read ↗

A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations.Semantic proximity Read ↗

Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.Semantic proximity Read ↗

Differential p53, p21, mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53.Semantic proximity Read ↗

Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.