Article
Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice.
Developmental biology - 1 Jun 1999
Wehrle-Haller B, Weston J A
Abstract excerpt
The normal products of the murine Steel (Sl) and Dominant white spotting (W) genes are essential for the development of melanocyte precursors, germ cells, and hematopoietic cells. The Sl locus encodes stem cell factor (SCF), which is the ligand of c-kit, a receptor tyrosine kinase encoded by the W locus. One allele of the Sl mutation, Sl17H, exhibits minor hematopoietic defects, sterility only in males, and a...
Topics
- Animals
- Biotinylation
- Cell Adhesion
- Cell Line
- Cell Movement
- Embryo, Mammalian
- Gene Expression Regulation, Developmental
- Immunohistochemistry
- In Situ Hybridization
- Intramolecular Oxidoreductases
- Melanocytes