Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vaccinia virus directs the synthesis of early mRNAs containing 5' poly(A) sequences.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Ink B S, Pickup D J

Abstract excerpt

mRNAs transcribed from late promoters of several poxvirus genes contain 5' poly(A) sequences that are not complementary to the viral DNA. In contrast, early mRNAs containing 5' poly(A) sequences have not previously been identified. Modifications to the sequence of the promoter of an early gene of cowpox virus enable this promoter to direct the synthesis of RNAs containing 5' poly(A) sequences. When the sequence...

Topics

Base Sequence
Cell Transformation, Viral
Genes, Viral
Genetic Vectors
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Poly A
Promoter Regions, Genetic
RNA, Messenger
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vaccinia virus

Source

Open in PubMed Open full text

Identifiers

PMID: 1968253
DOI: 10.1073/pnas.87.4.1536
PMCID: PMC53510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1968253-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vaccinia virus directs the synthesis of early mRNAs containing 5' poly(A) sequences.PMID 1968253Read ↗

Vaccinia virus intermediate and late promoter elements are targeted by the TATA-binding protein.Semantic proximity Read ↗

La-related protein 4 is enriched in vaccinia virus factories and is required for efficient viral replication in primary human fibroblastsSemantic proximity Read ↗

Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by the distance between the promoter and the intron and is inhibited by U1 small nuclear RNP binding to the intervening donor.Semantic proximity Read ↗

Regulation of coronaviral poly(A) tail length during infection.Semantic proximity Read ↗

Identification of the vaccinia virus gene encoding an 18-kilodalton subunit of RNA polymerase and demonstration of a 5' poly(A) leader on its early transcript.Semantic proximity Read ↗

The 5' end of coronavirus minus-strand RNAs contains a short poly(U) tractSemantic proximity Read ↗

Transcriptional analysis of multigene family 110 of African swine fever virusSemantic proximity Read ↗

A splicing enhancer in the E4 coding region of human papillomavirus type 16 is required for early mRNA splicing and polyadenylation as well as inhibition of premature late gene expression.Semantic proximity Read ↗

Human polyomavirus JCV late leader peptide region contains important regulatory elementsSemantic proximity Read ↗

Map of cis-acting sequences that determine alternative pre-mRNA processing in the E3 complex transcription unit of adenovirus.Semantic proximity Read ↗

Autogenous Translational Regulation of the Borna Disease Virus Negative Control Factor X from Polycistronic mRNA Using Host RNA HelicasesSemantic proximity Read ↗

An element downstream of the transcription start site is required for activation of Bombyx mori nucleopolyhedrovirus bro-c promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.