Cell-type-specific growth restriction of vesicular stomatitis virus polR mutants is linked to defective viral polymerase function.

doi:10.1128/JVI.01217-06

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Article

Cell-type-specific growth restriction of vesicular stomatitis virus polR mutants is linked to defective viral polymerase function.

Journal of virology - 1 Jan 2007

Ostertag Derek, Hoblitzell-Ostertag Traci M, Perrault Jacques

Abstract excerpt

Vesicular stomatitis virus polR mutants synthesize defective RNA replication products in vitro and display growth restriction in some cultured cells (J. L. Chuang, R. L. Jackson, and J. Perrault, Virology 229:57-67, 1997). We show here that a recombinant virus carrying the polR N protein mutation (R179H) yielded approximately 100-fold- and approximately 40-fold-lower amounts of infectious virus than the wild type...

Topics

Animals
Cell Line
Cricetinae
DNA-Directed RNA Polymerases
L Cells
Mice
Mutation
RNA, Double-Stranded
RNA, Viral
Rats
Species Specificity
Vesicular stomatitis Indiana virus
Virion
Virus Replication

Source

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Identifiers

PMID: 17065214
DOI: 10.1128/JVI.01217-06
PMCID: PMC1797469

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