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Article

Monocytic differentiation induced by side-chain modified analogs of vitamin D in ex vivo cells from patients with acute myeloid leukemia.

Leukemia research - 1 May 2014

Baurska Hanna, Kiełbiński Marek, Biecek Przemysław, Haus Olga, Jaźwiec Bożena, Kutner Andrzej, Marcinkowska Ewa

Abstract excerpt

The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D3, was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-differentiation activities, PRI-1907 even at a very low concentration. Our study revealed a high variability of individual...

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Identifiers

PMID: 24703772
DOI: 10.1016/j.leukres.2014.03.009

Genes

FLT3
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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