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Mechanisms of genome instability from cellular folate stress

29 Jul 2025

Abstract excerpt

Folate is the key cofactor in one-carbon metabolism, a universal metabolic pathway crucial for supporting the biosynthesis of nucleotides, several amino acids, and key redox regulators. Mammals are unable to synthesize folate de novo, and folate deficiency can result from several causes, including restricted dietary intake, genetic defects in folate absorption and its metabolism, and exposure to antimetabolite...

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PMID: 40824400
DOI: 10.1083/jcb.202502205

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