Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mRNA Metabolism Links with the DNA Damage Response.

Genes - 20 Sept 2021

Vadivel Gnanasundram Sivakumar, Bonczek Ondrej, Wang Lixiao, Chen Sa, Fahraeus Robin

Abstract excerpt

Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function of oncogenes or tumor suppressors, resulting in cancer development. To circumvent this, cells activate the DNA damage response (DDR), which mainly involves cell cycle regulation and DNA repair processes. The tumor suppressor p53 plays a pivotal role in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA-Binding Proteins

Share to RNA, Messenger

Share to RNA Research and Splicing

Share to Tumor Suppressor Protein p53

Share to Untranslated Regions

Source

Open in PubMed Open full text

Identifiers

PMID: 34573428
DOI: 10.3390/genes12091446
PMCID: PMC8465283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mRNA Metabolism Links with the DNA Damage Response.PMID 34573428Read ↗

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathwaysSemantic proximity Read ↗

Novel regulators and molecular mechanisms of p53R2 and its disease relevance.Semantic proximity Read ↗

Exploring the multiple roles of guardian of the genome: P53Semantic proximity Read ↗

Multiple roles of p53 in cancer development: Regulation of tumor microenvironment, m6A modification and diverse cell death mechanismsSemantic proximity Read ↗

p53 Biological Network: At the Crossroads of the Cellular-Stress Response Pathway and Molecular CarcinogenesisSemantic proximity Read ↗

DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunitiesSemantic proximity Read ↗

p53 Function and Dysfunction in Human Health and DiseasesSemantic proximity Read ↗

New insights into p53 functions through its target microRNAsSemantic proximity Read ↗

The P53 pathway: what questions remain to be explored?Semantic proximity Read ↗

Battle Against Cancer: An Everlasting Saga of p53Semantic proximity Read ↗

Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer StrategiesSemantic proximity Read ↗

Surf the Post-translational Modification Network of p53 RegulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.