Article
The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule.
European journal of immunology - 1 Nov 1996
Vartdal F, Johansen B H, Friede T, Thorpe C J, Stevanović S, Eriksen J E, Sletten K, Thorsby E, Rammensee H G, Sollid L M
Abstract excerpt
To identify the binding motifs of peptides which bind to the celiac disease and insulin-dependent-diabetes-mellitus (IDDM)-associated DQ2 molecule, peptides were eluted from affinity-purified DQ2 molecules. The eluted peptides were separated by reverse-phase HPLC. Prominent peptide peaks and the remaining pool of peptides were sequenced by Edman degradation. Truncated variants of eight different peptides with a...
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