Article
The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule.
European journal of immunology - 1 Nov 1996
Vartdal F, Johansen B H, Friede T, Thorpe C J, Stevanović S, Eriksen J E, Sletten K, Thorsby E, Rammensee H G, Sollid L M
Abstract excerpt
To identify the binding motifs of peptides which bind to the celiac disease and insulin-dependent-diabetes-mellitus (IDDM)-associated DQ2 molecule, peptides were eluted from affinity-purified DQ2 molecules. The eluted peptides were separated by reverse-phase HPLC. Prominent peptide peaks and the...
Topics
- Alleles
- Amino Acid Sequence
- Celiac Disease
- Diabetes Mellitus, Type 1
- HLA-DQ Antigens
- Humans
- Ligands
- Molecular Sequence Data
- Peptide Fragments
- Protein Binding
- Sequence Alignment