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Article

Immunopeptidomics-driven MHC class II peptide-binding motif discovery for 2 common canine DR alleles.

Journal of immunology (Baltimore, Md. : 1950) - 29 Aug 2026

Lang Haeree P, Rana Aysha, Almeer Farah F, Dileepan Thamotharampillai, Jenkins Marc, Friedenberg Steven G

Abstract excerpt

Despite the central role of major histocompatibility complex (MHC) class II in adaptive immunity, peptide-binding motifs have yet to be characterized for any canine MHC class II allele. Here, we report the first immunopeptidomics-derived binding motifs for DLA-DRB1*015:01 (DLA-DR15) and DLA-DRB1*012:01 (DLA-DR12), 2 alleles overrepresented in breeds predisposed to immune-mediated diseases. Because dogs co-express...

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Topics

Animals
Dogs
Alleles
Histocompatibility Antigens Class II
Peptides
Amino Acid Motifs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Binding

Proteomics

Source

Identifiers

PMID: 42752862
DOI: 10.1093/jimmun/vkag243

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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