Article
Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells.
Neuron - 1 Jul 1994
Barker P A, Shooter E M
Abstract excerpt
The role of the low affinity neurotrophin receptor, p75LNTR, in NGF-mediated signal transduction has been examined. Our results show that treatment of PC12 cells with MC192, a monoclonal antibody directed against p75LNTR, results in reduced NGF binding to TrkA and attenuated TrkA activation. Use...
Topics
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Binding, Competitive
- Brain-Derived Neurotrophic Factor
- Genes, fos
- Immunosorbent Techniques
- Molecular Sequence Data
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins
- PC12 Cells
- Phosphorylation
- Phosphotyrosine
- Proto-Oncogene Proteins
- RNA, Messenger
- Receptor Protein-Tyrosine Kinases
- Receptor, trkA