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Article

Expression of the multiple drug resistance gene (mdr-1) and epitope masking in chronic lymphatic leukaemia.

British journal of haematology - 1 Oct 1990

Cumber P M, Jacobs A, Hoy T, Fisher J, Whittaker J A, Tsuruo T, Padua R A

Abstract excerpt

Resistance to cytotoxic agents is a common clinical problem in the treatment of chronic lymphatic leukaemia (CLL). The multidrug resistant (MDR) phenotype characterized by increased levels of a specific cell membrane p-glycoprotein, confers cross resistance to a wide range of structurally dissimilar antineoplastic drugs. We have studied the expression of this p-glycoprotein in chronic lymphatic leukaemia measured...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antibodies, Monoclonal
Antigens, CD
Antineoplastic Combined Chemotherapy Protocols
B-Lymphocytes
Cell Line
Chlorambucil
Drug Resistance
Epitopes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Lymphocytic, Chronic, B-Cell

Membrane Glycoproteins

Neuraminidase

Phenotype

RNA, Messenger

Reference Values

T-Lymphocytes

Transcription, Genetic

Source

Identifiers

PMID: 1709806
DOI: 10.1111/j.1365-2141.1990.tb07876.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1709806-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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