Article
Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death.
Journal of leukocyte biology - 1 Feb 2007
Mehrotra Shikhar, Chhabra Arvind, Hegde Upendra, Chakraborty Nitya G, Mukherji Bijay
Abstract excerpt
Cytolytic T lymphocytes (CTL) play an important role in defense against viral infections. Following clonal expansion and effector functions, a vast majority of the antigen-specific CTL undergoes programmed cell death to maintain homeostasis. We have shown earlier that melanoma epitope-specific CTL are quite sensitive to activation-induced cell death (AICD) even on the secondary encounter of the antigen. Excessive...
Topics
- Anthracenes
- Apoptosis
- Biomarkers
- Cell Death
- Cells, Cultured
- Coculture Techniques
- Epitopes, T-Lymphocyte
- Humans
- Influenza A virus
- JNK Mitogen-Activated Protein Kinases
- Phenotype
- Protein Kinase Inhibitors
- Sensitivity and Specificity
- Structure-Activity Relationship