Article
CYP1A1 mutations 4887A, 4889G, 5639C and 6235C in the Polish population and their allelic linkage, determined by peptide nucleic acid-mediated PCR clamping.
Pharmacogenetics - 1 Aug 1997
Mrozikiewicz P M, Cascorbi I, Brockmöller J, Roots I
Abstract excerpt
Mutations in the CYP1A1 gene were investigated in 324 Polish children and adolescents using PCR/RFLP. Mutation T6235C (m1) occurred in 6.6% of alleles (95& confidence limits 4.8%-8.8%); A4889G (m2), 2.2% (1.2%-3.6%); and C4887A (m4), 2.0% (1.1%-3.4%). T5639C (m3) was not detected. Wild-type allele CYP1A1*1 was found in 91.4% (88.9%-93.4%). In all cases of theoretically possible mutation linkages, the novel method...
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