Article
Analysis of HPV16 E6 and mutant p53-transfected keratinocytes in reconstituted epidermis suggests that wild-type p53 inhibits cytokeratin 19 expression.
Journal of cell science - 1 Feb 1994
Molès J P, Schiller J T, Tesniere A, Leigh I M, Guilhou J J, Basset-Séguin N
Abstract excerpt
Using a reconstituted skin culture model we have analysed the effects of oncogenic human papillomavirus (HPV) and mutant TP53 genes on the proliferation and differentiation of human keratinocytes. Immortal cell lines generated by transfection of early passage normal human keratinocytes with HPV16...
Topics
- Cell Differentiation
- Cell Division
- Cell Line
- Culture Techniques
- Gene Expression
- Genes, Viral
- Genes, p53
- Humans
- Keratinocytes
- Keratins
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins
- Phenotype
- Repressor Proteins
- Skin
- Skin Neoplasms